Pengaruh Penambahan Propilen Glikol, Tween 80, Tween 20 dan PEG 400 Terhadap Kelarutan Furosemide

  • Rahmadevi Rahmadewi Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Abstract

Abstract


Solubility of Active Pharmaceutical Ingredient is an important role in the formulation of a pharmaceutical preparation. Drugs that have a small solubility showed low bioavailability. Furosemide is a strong diuretic has a solubility value of 0,01 mg/ ml and log P 0,74 that are classified into the BCS (Biopharmaceutics Classification System) class 4, are a drug which has low solubility and low permeability. In this study, the addition of surfactants are P


Abstract


Solubility of Active Pharmaceutical Ingredient is an important role in the formulation of a pharmaceutical preparation. Drugs that have a small solubility showed low bioavailability. Furosemide is a strong diuretic has a solubility value of 0,01 mg/ ml and log P 0,74 that are classified into the BCS (Biopharmaceutics Classification System) class 4, are a drug which has low solubility and low permeability. In this study, the addition of surfactants are PEG 400, Tween 80, tween 20, and propilenglikol to increase the solubility of Furosemide. Each of these surfactants measured surface tension in order to get the point of the CMC to view the solubility of 10 mg of furosemide were measured by UV spectrophotometer. Results of the research that has been conducted on concentration obtained CMC point PEG 400, Tween 80, tween 20, and propilenglikol respectively from 0,19 to 0,22%; 0,2 to 0,22% and 6-8%. Based on these results an increase in the solubility of Furosemide.


Keywords : Solubilization, CMC point, FurosemideEG 400, Tween 80, tween 20, and propilenglikol to increase the solubility of Furosemide. Each of these surfactants measured surface tension in order to get the point of the CMC to view the solubility of 10 mg of furosemide were measured by UV spectrophotometer. Results of the research that has been conducted on concentration obtained CMC point PEG 400, Tween 80, tween 20, and propilenglikol respectively from 0,19 to 0,22%; 0,2 to 0,22% and 6-8%. Based on these results an increase in the solubility of Furosemide.


Keywords : Solubilization, CMC point, Furosemide

Published
2015-11-30
How to Cite
RAHMADEWI, Rahmadevi. Pengaruh Penambahan Propilen Glikol, Tween 80, Tween 20 dan PEG 400 Terhadap Kelarutan Furosemide. Tropharm (Trobosan Pharmacy), [S.l.], v. 1, n. 2, p. 36-42, nov. 2015. Available at: <http://www.stikes-hi.ac.id/jurnal/index.php/tropharm/article/view/295>. Date accessed: 11 aug. 2020.